Kazushi Numata Selected Research

perfluorobutane (AI 700)

1/2020	Use of intra-procedural fusion imaging combining contrast-enhanced ultrasound using a perflubutane-based contrast agent and auto sweep three-dimensional ultrasound for guiding radiofrequency ablation and evaluating its efficacy in patients with hepatocellular carcinoma.
1/2019	Differential diagnosis of gallbladder polypoid lesions using contrast-enhanced ultrasound.
10/2015	Use of vessel patterns on contrast-enhanced ultrasonography using a perflubutane-based contrast agent for the differential diagnosis of regenerative nodules from early hepatocellular carcinoma or high-grade dysplastic nodules in patients with chronic liver disease.
1/2014	Contrast-enhanced ultrasonography findings using a perflubutane-based contrast agent in patients with early hepatocellular carcinoma.
9/2013	Use of contrast-enhanced ultrasonography with a perflubutane-based contrast agent performed one day after transarterial chemoembolization for the early assessment of residual viable hepatocellular carcinoma.
10/2012	Use of fusion imaging combining contrast-enhanced ultrasonography with a perflubutane-based contrast agent and contrast-enhanced computed tomography for the evaluation of percutaneous radiofrequency ablation of hypervascular hepatocellular carcinoma.
8/2010	Evaluation of the therapeutic efficacy of high-intensity focused ultrasound ablation of hepatocellular carcinoma by three-dimensional sonography with a perflubutane-based contrast agent.
5/2010	Differentiation of focal liver lesions using three-dimensional ultrasonography: retrospective and prospective studies.
2/2010	Contrast enhanced ultrasound of hepatocellular carcinoma.
4/2009	Focal liver tumors: characterization with 3D perflubutane microbubble contrast agent-enhanced US versus 3D contrast-enhanced multidetector CT.

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Kazushi Numata Research Topics

Disease

96	Hepatocellular Carcinoma (Hepatoma) 04/2024 - 01/2002
51	Neoplasms (Cancer) 02/2024 - 01/2002
8	Necrosis 01/2022 - 01/2002
8	Neoplasm Metastasis (Metastasis) 06/2020 - 01/2002
7	Fibrosis (Cirrhosis) 02/2024 - 06/2005
6	Liver Neoplasms (Liver Cancer) 10/2021 - 02/2012
6	Liver Diseases (Liver Disease) 10/2020 - 02/2015
5	Thrombosis (Thrombus) 02/2021 - 01/2011
4	Infections 01/2023 - 11/2002
4	Disease Progression 05/2022 - 04/2011
4	Chronic Hepatitis C 03/2021 - 01/2010
3	Hypertension (High Blood Pressure) 04/2024 - 01/2020
3	Fatigue 05/2022 - 01/2016
3	Thrombocytopenia (Thrombopenia) 05/2022 - 06/2020
3	Hemorrhage 04/2022 - 01/2002
3	Liver Cirrhosis (Hepatic Cirrhosis) 03/2021 - 05/2003
3	Residual Neoplasm 03/2012 - 03/2005
3	Focal Nodular Hyperplasia 05/2010 - 03/2007
3	Hemangioma (Angioma) 05/2010 - 03/2007
2	Proteinuria 05/2022 - 01/2020
2	Polyps 04/2021 - 06/2007
2	Fever (Fevers) 06/2020 - 01/2016
2	Vomiting 01/2020 - 01/2016
2	Diarrhea 01/2020 - 01/2016
2	Hepatitis B 07/2019 - 11/2002
2	Ascites 02/2015 - 05/2003
2	Stomach Neoplasms (Stomach Cancer) 06/2014 - 01/2002
2	Hepatic Encephalopathy 12/2013 - 05/2003
2	Colorectal Neoplasms (Colorectal Cancer) 10/2010 - 07/2010
1	Leukopenia 04/2024
1	Carcinogenesis 01/2023
1	Anorexia 05/2022
1	Sudden Death 05/2022
1	Neoplasms, Cystic, Mucinous, and Serous 08/2021
1	Hyperglycemia 08/2021

Drug/Important Bio-Agent (IBA)

23	Sorafenib (BAY 43-9006)FDA Link 05/2023 - 04/2011
21	Contrast MediaIBA 01/2022 - 09/2002
13	lenvatinibIBA 04/2024 - 01/2020
12	perfluorobutane (AI 700)IBA 01/2020 - 03/2008
10	SonazoidIBA 06/2021 - 03/2008
7	Bevacizumab (Avastin)FDA Link 03/2024 - 01/2020
7	atezolizumabIBA 03/2024 - 01/2020
7	GadoliniumIBA 06/2021 - 01/2012
7	gadolinium ethoxybenzyl DTPA FDA Link 01/2017 - 01/2012
6	Pentetic Acid (DTPA)FDA LinkGeneric 06/2021 - 01/2012
4	Cisplatin (Platino)FDA LinkGeneric 04/2024 - 01/2002
4	Biomarkers (Surrogate Marker)IBA 02/2024 - 08/2012
4	BilirubinIBA 02/2021 - 01/2017
4	Therapeutic UsesIBA 07/2020 - 07/2003
4	Messenger RNA (mRNA)IBA 06/2014 - 07/2010
4	Ethanol (Ethyl Alcohol)IBA 10/2008 - 09/2002
3	Antiviral Agents (Antivirals)IBA 01/2023 - 12/2013
3	AlbuminsIBA 02/2021 - 02/2015
3	NivolumabIBA 01/2021 - 01/2019
2	Aspartate Aminotransferases (Aspartate Transaminase)IBA 04/2024 - 05/2022
2	Alanine Transaminase (SGPT)IBA 04/2024 - 05/2022
2	3,7,11,15- tetramethyl- 2,4,6,10,14- hexadecapentaenoic acidIBA 02/2024 - 06/2015
2	cabozantinibIBA 05/2023 - 01/2021
2	acarboxyprothrombin (PIVKA)IBA 11/2020 - 01/2017
2	Fluorouracil (Carac)FDA LinkGeneric 01/2017 - 01/2002
2	(2E,4E,6E,10E)- 3,7,11,15- tetramethyl- 2,4,6,10,14- hexadecapentaenoic acidIBA 06/2015 - 02/2015
2	Proteins (Proteins, Gene)FDA Link 06/2014 - 05/2013
2	alpha-Fetoproteins (alpha-Fetoprotein)IBA 05/2013 - 03/2013
2	Vitamin K FDA Link 05/2013 - 02/2007
2	Serum AlbuminIBA 05/2013 - 02/2007
2	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 10/2010 - 07/2010
2	Tissue Inhibitor of Metalloproteinase-1IBA 10/2010 - 07/2010
2	Indicators and Reagents (Reagents)IBA 04/2010 - 11/2002
2	SuspensionsIBA 02/2010 - 03/2008
2	LipidsIBA 02/2010 - 03/2008
2	Galactose (Galactopyranose)FDA LinkGeneric 03/2007 - 01/2003
2	Palmitic Acid (Hexadecanoic Acid)IBA 03/2007 - 01/2003
2	GelatinIBA 06/2005 - 10/2004
2	Iodized OilIBA 06/2005 - 10/2004
2	SHU 508 (Levovist)IBA 07/2003 - 09/2002
1	N-Myc Proto-Oncogene ProteinIBA 02/2024
1	Vitamin A (Retinol)FDA LinkGeneric 02/2024
1	Immune Checkpoint InhibitorsIBA 01/2023
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 08/2022
1	EnzymesIBA 01/2022
1	C-PeptideIBA 08/2021
1	Insulin (Novolin)FDA Link 08/2021
1	PENTAIBA 04/2021
1	diethylenetriamineIBA 04/2021
1	Acetic Acid (Vinegar)FDA LinkGeneric 04/2021
1	sofosbuvir drug combination ledipasvirIBA 03/2021
1	SofosbuvirIBA 03/2021

Therapy/Procedure

35	Therapeutics 01/2023 - 01/2002
22	Radiofrequency Ablation 01/2022 - 01/2002
9	Drug Therapy (Chemotherapy) 04/2024 - 01/2002
3	Radiotherapy 04/2022 - 01/2019
3	High-Intensity Focused Ultrasound Ablation 12/2013 - 08/2010
3	Microbubbles 02/2010 - 03/2008
2	Intra-Arterial Infusions 04/2024 - 10/2008
2	Surgical Instruments (Clip) 04/2022 - 02/2021
2	Liver Transplantation 10/2021 - 05/2004
2	Stents 02/2021 - 08/2020
2	Punctures 01/2018 - 08/2014
1	Molecular Targeted Therapy 01/2022
1	Hepatectomy 02/2021